Recombinant Human IL23A, FLAG-tagged

• Cat.No.: IL23A-29781TH
• Product Overview: Recombinant full length Human IL 23 p40 peptide fused at the C terminus to an 18 amino acid linker peptide and to IL23 P19 and fused at the N terminus to a DDDDK tag; Mwt: 75 kDa by SDS PAGE.

Specification

• Description: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
• Protein length: 170 amino acids
• Conjugation: FLAG
• Molecular Weight: 75.000kDa inclusive of tags
• Source: HEK 293 cells
• Tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
• Biological activity: Induction of IL17 secretion by Mouse splenocytes.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Constituent:99% PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the IL-6 superfamily.

Gene Information

• Gene Name: IL23A interleukin 23, alpha subunit p19 [ Homo sapiens ]
• Official Symbol: IL23A
• Synonyms: IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF
• Gene ID: 51561
• mRNA Refseq: NM_016584
• Protein Refseq: NP_057668
• MIM: 605580
• Uniprot ID: Q9NPF7
• Chromosome Location: 12q13.13
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem
• Function: cytokine activity; contributes_to interleukin-23 receptor binding