Recombinant Human IL23A Protein, His-tagged
Cat.No. : | IL23A-2303H |
Product Overview : | Recombinant Human IL23A Protein (Ile23-Ser328+GSGSSRGGSGSGGSGGGGSKL+Arg20-Pro189) with a N-His tag was expressed in 293F. |
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Description : | This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. |
Source : | HEK293F |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 58.5 kDa Accurate Molecular Mass: 60 kDa |
Protein length : | Ile23-Ser328+GSGSSRGGSGSGGSGGGGSKL+Arg20-Pro189 |
Endotoxin : | <1.0 EU per 1µg (determined by the LAL method). |
Purity : | > 90% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | IL23A interleukin 23 subunit alpha [ Homo sapiens (human) ] |
Official Symbol : | IL23A |
Synonyms : | IL23A; interleukin 23 subunit alpha; P19; SGRF; IL-23; IL-23A; IL23P19; interleukin-23 subunit alpha IL-23 subunit alpha IL-23-A IL-23p19 JKA3 induced upon T-cell activation interleukin 23 p19 subunit interleukin 23, alpha subunit p19 interleukin-23 subunit p19 interleukin-six, G-CSF related factor |
Gene ID : | 51561 |
mRNA Refseq : | NM_016584 |
Protein Refseq : | NP_057668 |
MIM : | 605580 |
UniProt ID : | Q9NPF7 |
Products Types
◆ Recombinant Protein | ||
Il23a-3515M | Active Recombinant Mouse Il23a Protein | +Inquiry |
IL23A-2358H | Recombinant Human IL23A protein(Met1-Pro189), mFc-tagged | +Inquiry |
IL23A-02H | Recombinant Human Active IL23A Protein, His-tagged | +Inquiry |
IL23A-32H | Active Recombinant Human IL23A Protein, Animal Free | +Inquiry |
Il23A-23H | Recombinant Human Il23A&IL12B Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL23A-5231HCL | Recombinant Human IL23A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewCoupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.
Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.
Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.
Q&As (6)
Ask a questionPlease inquiry our product manager with specific product.
Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.
IL23A primarily plays a role in regulating the adaptive immune response.
IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.
In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.
IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.
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