IL33-29791TH
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Human IL33(aa 112-270) fused with FLAG tag at C-terminal was expressed in HEK293.
Description :
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Source :
HEK293
Species :
Human
Tag :
FLAG
Form :
Liquid. 0.2μm-filtered solution in PBS, pH 7.2.
Bio-activity :
Activates human ST2-dependent NF-κB pathway.
Molecular Mass :
~23kDa (SDS-PAGE)
Endotoxin :
<0.1EU/μg purified protein (LAL test; Lonza).
Purity :
≥90% (SDS-PAGE)
Stability :
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Storage :
Short Term Storage +4 centigrade;Long Term Storage -20 centigrade;After opening, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.