Recombinant Human IL7RA protein, Fc-tagged

• Cat.No.: IL7RA-328H
• Product Overview: Recombinant Human IL7RA protein (Glu21-Gly236), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293).

Specification

• Description: Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra/CD127 contains 1 fibronectin type-III domain. IL7Ra/CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra/CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 51.0 kDa. The protein migrates as 66-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: 216
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IL7RA
• Official Symbol: IL7RA
• Synonyms: ILRA; CD127; IL7RA; CDW127; IL-7R-alpha
• Gene ID: 3575
• mRNA Refseq: NM_002185.5
• Protein Refseq: NP_002176.2
• MIM: 146661
• UniProt ID: P16871

Reviews

05/09/2022

This synthesis cost and application cost are moderate, and it is more cost-effective for production.

11/11/2020

IL7RA has good stability and consistency in the process of mass production.

02/14/2019

Long-lasting effects and sustained release properties.

Q&As

Can AIDS be prevented by IL7RA?

It is not used to prevent AIDS methods, currently mainly used for disease treatment.

Is IL7RA associated with immunity enhancement?

Yes, the IL7RA can enhance the function of immune cells and thus enhance immunity.

Does the use of IL7RA require special storage conditions?

Yes, the IL7RA needs to be stored under low temperature and dry conditions to maintain its stability.

Is recombinant IL7RA associated with cancer?

IL7RA has also been studied in cancer immunotherapy, but the specific effect needs to be further verified.

What are the side effects of IL7RA?

The side effects of IL7RA include fever, headache, fatigue, etc. In rare cases, allergic reactions may occur.

What is the action mechanism of IL7RA?

This protein activates T cells and B cells by binding to IL-7 receptors, promoting the enhancement of immune response.