- Human(2)
Recombinant Human IL7RA protein, Fc-tagged
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Cat.No. : | IL7RA-328H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human IL7RA protein (Glu21-Gly236), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
Description : | Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra/CD127 contains 1 fibronectin type-III domain. IL7Ra/CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra/CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 51.0 kDa. The protein migrates as 66-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 216 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
SDS-PAGE of IL7RA-328H : |
![]() Human IL-7 R alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Bioactivity-ELISA of IL7RA-328H : |
![]() Immobilized Human IL-7, Tag Free at 2 μg/mL (100 μL/well) can bind Human IL-7 R alpha, Fc Tag with a linear range of 1-16 ng/mL (QC tested). |
Bioactivity-SPR of IL7RA-328H : |
![]() Captured Human IL-7R alpha, Fc Tag on CM5 chip via anti-human IgG Fc antibodies surface can bind ActiveMax® Human IL-7, Tag Free with an affinity constant of 23.9 nM as determined in a SPR assay (Routinely tested). |
Gene Name : | IL7RA |
Official Symbol : | IL7RA |
Synonyms : | ILRA; CD127; IL7RA; CDW127; IL-7R-alpha |
Gene ID : | 3575 |
mRNA Refseq : | NM_002185.5 |
Protein Refseq : | NP_002176.2 |
MIM : | 146661 |
UniProt ID : | P16871 |
◆ Recombinant Protein
IL7RA-324H | Recombinant Human IL7RA protein, Mouse IgG2a Fc-tagged | +Inquiry |
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