Description : |
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
63.5 kDa |
AA Sequence : |
MESKDEVSDTDSGIILQSGPDSPVS PMKELTHAVHKQQRALEARLEACLE ELRRLCLREAELTGTLPAEYPLKPG EKAPKVRRRIGAAYKLDDWALHRED PLSSLERQLALQLQITEAARRLCLE ENLSRQARRQRKHSMLQEEKKLQEL QRCLVERRRNSEPPPAAALPLGREL SASDDSSLSDGLLLEEEESQVPKPP PESPAPPSRPLPPQTLEGLQPTGPE AGSPERAPVQNSPWKETSLDHPYEK PRKSSEPWSESSSPATTPQDGPSAS SLWLLEPASYHVVPIRGVPGQWQGR TSAPATPEIQGRRGQSQSLRVDSFR AGPEGRGRSAFPRRRPTHYTVTVPD SCFPATKPPLPHAACHSCSEDSGSD VSSISHPTSPGSSSPDISFLQPLSP PKTHRHRGAWVPAGSRELVAHHPKL LLPPGYFPAGRYVVVAESPLPPGEW ELCRAAPGPAYEEEGTPLRYQRLVP SRSRIVRTPSLKDSPAGRGLSKAAV SEELKWWHERARLRSTRPHSLDRQG AFRVRSLPLGREGFGRALGPRAQVP TVCVLRRSPDGAPVQVFVPEKGEII SQVTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |