"INS" Related Products

Recombinant Human INS Protein, His/GST-tagged

Cat.No.: INS-674H
Product Overview: Recombinant Human INS(Phe25~Asn110) fused with His/GST tag at N-terminal was expressed in E. coli.
Description: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
Source: E. coli
Species: Human
Tag : His/GST
Form: 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass: 39.4kDa
Identity: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Protein length: Phe25~Asn110
Endotoxin: <1.0EU per 1µg (determined by the LAL method)
Purity: > 95%
Applications: Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution: Reconstitute in PBS or others
Gene Name: INS insulin [ Homo sapiens ]
Official Symbol: INS
Synonyms: INS; insulin; proinsulin; ILPR; IRDN; IDDM2; MODY10;
Gene ID: 3630
mRNA Refseq: NM_000207
Protein Refseq: NP_000198
UniProt ID: P01308

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