Recombinant Human IRAK4 Protein, GST-tagged
Cat.No. : | IRAK4-5049H |
Product Overview : | Human IRAK4 full-length ORF ( AAH13316.1, 1 a.a. - 460 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 76.34 kDa |
AA Sequence : | MNKPITPSTYVRCLNVGLIRKLSDF IDPQEGWKKLAVAIKKPSGDDRYNQ FHIRRFEALLQTGKSPTSELLFDWG TTNCTVGDLVDLLIQNEFFAPASLL LPDAVPKTANTLPSKEAITVQQKQM PFCDKDRTLMTPVQNLEQSYMPPDS SSPENKSLEVSDTRFHSFSFYELKN VTNNFDERPISVGGNKMGEGGFGVV YKGYVNNTTVAVKKPAAMVDITTEE LKQQFDQEIKVMAKCQHENLVELLG FSSDGDDLCLVYVYMPNGSLLDRLS CLDGTPPLSWHMRCKIAQGAANGIN FLHENHHIHRDIKSANILLDEAFTA KISDFGLARASEKFAQTVMTSRIVG TTAYMAPEALRGEITPKSDIYSFGV VLLEIITGLPAVDEHREPQLLLDIK EEIEDEEKTIEDYIDKKMNDADSTS VEAMYSVASQCLHEKKNKRPDIKKV QQLLQEMTAS |
Applications : | Kinase Assay Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ] |
Official Symbol : | IRAK4 |
Synonyms : | IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64; |
Gene ID : | 51135 |
mRNA Refseq : | NM_001114182 |
Protein Refseq : | NP_001107654 |
MIM : | 606883 |
UniProt ID : | Q9NWZ3 |
Products Types
◆ Recombinant Protein | ||
IRAK4-058H | Recombinant Human IRAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Irak4-0058M | Recombinant Mouse Irak4 protein(Ser169-Ala459), His-tagged | +Inquiry |
IRAK4-1107H | Recombinant Human IRAK4 protein(Met1-Ser336), His-tagged | +Inquiry |
Irak4-3570M | Recombinant Mouse Irak4 Protein, Myc/DDK-tagged | +Inquiry |
IRAK4-35H | Recombinant Human IRAK4 Protein, His tagged | +Inquiry |
◆ Lysates | ||
IRAK4-615HCL | Recombinant Human IRAK4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionRheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.
Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.
Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.
Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.
By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.
Customer Reviews (3)
Write a reviewIts potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.
Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.
They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.
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