Recombinant Human IRAK4 protein, Flag-tagged, Biotinylated
Cat.No. : | IRAK4-54H |
Product Overview : | Recombinant Human IRAK4 [1-460(end) amino acids of accession number NP_057207.2] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated. |
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Source : | Insect cell |
Species : | Human |
Tag : | Flag |
Form : | 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5 |
Molecular Mass : | 55 kDa |
Purity : | >90% as determined by SDS-PAGE and CBB staining |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Protein length : | 1-460 |
Gene Name : | IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ] |
Official Symbol : | IRAK4 |
Synonyms : | IRAK4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64; |
Gene ID : | 51135 |
mRNA Refseq : | NM_001114182 |
Protein Refseq : | NP_001107654 |
MIM : | 606883 |
UniProt ID : | Q9NWZ3 |
Chromosome Location : | 12q12 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; |
Function : | ATP binding; interleukin-1 receptor binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
IRAK4-1107H | Recombinant Human IRAK4 protein(Met1-Ser336), His-tagged | +Inquiry |
IRAK4-1169H | Recombinant Human IRAK4 Protein (E154-S460), His tagged | +Inquiry |
IRAK4-5049H | Recombinant Human IRAK4 Protein, GST-tagged | +Inquiry |
Irak4-3570M | Recombinant Mouse Irak4 Protein, Myc/DDK-tagged | +Inquiry |
IRAK4-1193H | Recombinant Human IRAK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IRAK4-615HCL | Recombinant Human IRAK4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.
Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.
They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.
Q&As (5)
Ask a questionRheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.
Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.
Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.
Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.
By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.
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