Recombinant Human ITGA4 & ITGB7 protein, His-Avi-tagged

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Recombinant Human ITGA4 & ITGB7 protein, His-Avi-tagged

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Cat.No. : ITGA4 & ITGB7-890H
Product Overview : Recombinant Human Integrin ITGA4&ITGB7 Protein is expressed from mammalian with a His Tag and Avi Tag at the C-terminal. It contains Tyr 34 - Thr 977 (P13612) acidic tail& Glu20-His723 (P26010) basic tail.
Description : Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0. 22um filtered solution in PBS (pH 7. 4).
Molecular Mass : The protein has a predicted MW of 112. 5 kDa (P13612) & 81. 3 kDa (P26010). Due to glycosylation, the protein migrates to 70 kDa, 80 kDa and 130-150 kDa & 100-120 kDa based on Bis-Tris PAGE result
Protein length : It contains Tyr 34 - Thr 977 (P13612) acidic tail& Glu20-His723 (P26010) basic tail.
Endotoxin : Less than 1EU per ug by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Tris-Bis PAGE :

HPLC data :

Gene Name : ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [ Homo sapiens ]
Official Symbol : ITGA4; ITGB7
Synonyms : Integrin alpha 4 beta 7; beta7; alpha 4;LPAM
Gene ID : 3676
mRNA Refseq : NM_000885
Protein Refseq : NP_000876
MIM : 192975
UniProt ID : P13612

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