Recombinant Human ITGA8 Protein, GST-tagged ITGA8-4993H

Recombinant Human ITGA8 Protein, GST-tagged

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Recombinant Human ITGA8 Protein, GST-tagged

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Cat.No. : ITGA8-4993H
Product Overview : Human ITGA8 partial ORF ( NP_003629, 836 a.a. - 935 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : SDTILEVGWPFSARD EFLLYIFHIQTLGPL QCQPNPNINPQDIKP AASPEDTPELSAFLR NSTIPHLVRKRDVHV VEFHRQSPAKILNCT NIECLQISCA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue

Gene Name : ITGA8 integrin, alpha 8 [ Homo sapiens ]
Official Symbol : ITGA8
Synonyms : ITGA8; integrin, alpha 8; integrin alpha-8;
Gene ID : 8516
mRNA Refseq : NM_003638
Protein Refseq : NP_003629
MIM : 604063
UniProt ID : P53708

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