Recombinant Human ITGA8 Protein, His/GST-tagged ITGA8-246H

Recombinant Human ITGA8 Protein, His/GST-tagged

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Recombinant Human ITGA8 Protein, His/GST-tagged

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Cat.No. : ITGA8-246H
Product Overview : Recombinant Human ITGA8(Asp907~Ala1063) fused with His/GST tag at N-terminal was expressed in E. coli.
Description : Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Source : E. coli
Species : Human
Tag : His/GST
Form : 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 47.55kDa
Protein length : Asp907~Ala1063
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Figure :

Gene Name : ITGA8 integrin, alpha 8 [ Homo sapiens ]
Official Symbol : ITGA8
Synonyms : ITGA8; integrin, alpha 8; integrin alpha-8;
Gene ID : 8516
mRNA Refseq : NM_003638
Protein Refseq : NP_003629
MIM : 604063
UniProt ID : P53708

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