Recombinant Human ITGA8 Protein, MYC/DDK-tagged ITGA8-2613H

Recombinant Human ITGA8 Protein, MYC/DDK-tagged

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Recombinant Human ITGA8 Protein, MYC/DDK-tagged

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Cat.No. : ITGA8-2613H
Product Overview : Recombinant Human ITGA8 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 117.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ITGA8 integrin, alpha 8 [ Homo sapiens ]
Official Symbol : ITGA8
Synonyms : OTTHUMP00000019207; integrin, alpha 8
Gene ID : 8516
mRNA Refseq : NM_003638
Protein Refseq : NP_003629
MIM : 604063
UniProt ID : P53708

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