| Description : |
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
117.3 kDa |
| AA Sequence : |
MSPGASRGPRGSQAPLIAPLCCAAA ALGMLLWSPACQAFNLDVEKLTVYS GPKGSYFGYAVDFHIPDARTASVLV GAPKANTSQPDIVEGGAVYYCPWPA EGSAQCRQIPFDTTNNRKIRVNGTK EPIEFKSNQWFGATVKAHKGKVVAC APLYHWRTLKPTPEKDPVGTCYVAI QNFSAYAEFSPCRNSNADPEGQGYC QAGFSLDFYKNGDLIVGGPGSFYWQ GQVITASVADIIANYSFKDILRKLA GEKQTEVAPASYDDSYLGYSVAAGE FTGDSQQELVAGIPRGAQNFGYVSI INSTDMTFIQNFTGEQMASYFGYTV VVSDVNSDGLDDVLVGAPLFMEREF ESNPREVGQIYLYLQVSSLLFRDPQ ILTGTETFGRFGSAMAHLGDLNQDG YNDIAIGVPFAGKDQRGKVLIYNGN KDGLNTKPSQVLQGVWASHAVPSGF GFTLRGDSDIDKNDYPDLIVGAFGT GKVAVYRARPVVTVDAQLLLHPMII NLENKTCQVPDSMTSAACFSLRVCA SVTGQSIANTIVLMAEVQLDSLKQK GAIKRTLFLDNHQAHRVFPLVIKRQ KSHQCQDFIVYLRDETEFRDKLSPI NISLNYSLDESTFKEGLEVKPILNY YRENIVSEQAHILVDCGEDNLCVPD LKLSARPDKHQVIIGDENHLMLIIN ARNEGEGAYEAELFVMIPEEADYVG IERNNKGFRPLSCEYKMENVTRMVV CDLGNPMVSGTNYSLGLRFAVPRLE KTNMSINFDLQIRSSNKDNPDSNFV SLQINITAVAQVEIRGVSHPPQIVL PIHNWEPEEEPHKEEEVGPLVEHIY ELHNIGPSTISDTILEVGWPFSARD EFLLYIFHIQTLGPLQCQPNPNINP QDIKPAASPEDTPELSAFLRNSTIP HLVRKRDVHVVEFHRQSPAKILNCT NIECLQISCAVGRLEGGESAVLKVR SRLWAHTFLQRKNDPYALASLVSFE VKKMPYTDQPAKLPEGSIAIKTSVI WATPNVSFSIPLWVIILAILLGLLV LAILTLALWKCGFFDRARPPQEDMT DREQLTNDKTPEATRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
