Recombinant Human ITPA Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ITPA-2957H
• Product Overview: ITPA MS Standard C13 and N15-labeled recombinant protein (NP_258412) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 21.4 kDa
• AA Sequence: MAASLVGKKIVFVTGNAKKLEEVVQ ILGDKFPCTLVAQKIDLPEYQGEPD EISIQKCQEAVRQVQGPVLVEDTCL CFNALGGLPGPYIKWFLEKLKPEGL HQLLAGFEDKSAYALCTFALSTGDP SQPVRLFRGRTSGRIVAPRGCQDFG WDPCFQPDGYEQTYAEMPKAEKNAV SHRFRALLELQEYFGSLAATRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ITPA inosine triphosphatase [ Homo sapiens (human) ]
• Official Symbol: ITPA
• Synonyms: ITPA; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); C20orf37; inosine triphosphate pyrophosphatase; dJ794I6.3; HLC14 06 P; NTPase; My049 protein; inosine triphosphatase-A; putative oncogene protein HLC14-06-P; nucleoside triphosphate diphosphatase; nucleoside-triphosphate diphosphatase; non-standard purine NTP pyrophosphatase; nucleoside-triphosphate pyrophosphatase; non-canonical purine NTP pyrophosphatase; inosine triphosphate pyrophosphohydrolase; ITPase; HLC14-06-P
• Gene ID: 3704
• mRNA Refseq: NM_033453
• Protein Refseq: NP_258412
• MIM: 147520
• UniProt ID: Q9BY32