Description : |
Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408). |
Source : |
E. coli |
Species : |
Human |
Tag : |
His |
Molecular Mass : |
23.1 kDa |
Protein length : |
1-181 |
Purity : |
>95% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB). |
Applications : |
ELISA, Western Blot, Antibody Production, Protein array |
Quality Control Test : |
10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST monoclonal and peptide fingerprinting by MALDI-TOF mass spectrometry. |
Storage : |
Store working aliquots at 4 centigrade for up to one week. For extended storage, conserve at −80 centigrade. |
Expiry : |
12 months from the date of purchase, if it is properly stored. |
Storage Buffer : |
Phosphate-Buffered Saline (PBS), pH 7.4. No preservatives added. |
Shipping : |
Dry Ice |