Recombinant Human JPT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: JPT1-2820H
• Product Overview: HN1 MS Standard C13 and N15-labeled recombinant protein (NP_057269) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 15.8 kDa
• AA Sequence: MTTTTTFKGVDPNSRNSSRVLRPPG GGSNFSLGFDEPTEQPVRKNKMASN IFGTPEENQASWAKSAGAKSSGGRE DLESSGLQRRNSSEASSGDFLDLKG EGDIHENVDTDLPGSLGQSEEKPVP AAPVPSPVAPAPVPSRRNPPGGKSS LVLGTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: JPT1 Jupiter microtubule associated homolog 1 [ Homo sapiens (human) ]
• Official Symbol: JPT1
• Synonyms: JPT1; Jupiter microtubule associated homolog 1; HN1; ARM2; HN1A; jupiter microtubule associated homolog 1; androgen-regulated protein 2; hematological and neurological expressed 1 protein
• Gene ID: 51155
• mRNA Refseq: NM_016185
• Protein Refseq: NP_057269
• UniProt ID: Q9UK76