Recombinant Human K48-Linked Di-Ubiquitin, Biotinylated

• Cat.No.: Di-Ubiquitin-06H
• Product Overview: Recombinant Biotinylated Human K48-Linked Di-Ubiquitin without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Description: Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and we once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, the K48 linkage remains a critical pathway for cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These diubiquitin chains generated from the enzymatic linkage of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for the lysine at position 48, limiting chain length.
• Form: Liquid
• Molecular Mass: 17139.7 Da
• Applications: Optimization of pull-down conditions for anti-K48 TUBE and anti K63-TUBE reagents
• Storage: At -80 centigrade, avoid freeze/thaw cycles
• Storage Buffer: Phosphate Buffered Saline pH 7.4
• Conjugation: Biotin

Gene Information

• Official Symbol: Di-Ubiquitin
• Synonyms: Di-Ubiquitin; Ubiquitin; UBB