Recombinant Human KDR Protein, Fc-tagged, Alexa Fluor 555 conjugated

• Cat.No.: KDR-31716THAF555
• Product Overview: Alexa Fluor 555 conjugated recombinant fragment: human soluble Vascular Endothelial Growth Factor Receptor 2 (sVEGFR2) was fused with the Fc part of human IgG1 and expressed in Insect cells. The recombinantsVEGFR2/Fc is a disulfide-linked homodimeric protein, M.Wt of themonomer is

Specification

• Description: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
• Source: Insect cells
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Purity: > 90 % as determined by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 555 via amines
  With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters.
• Storage: Shipped at 4 centigrade. Upon delivery aliquot and store at -20 or -80 centigrade. Avoid repeated freeze/thaw cycles.
• Storage Buffer: PBS, pH 7.4
• Reconstitution: PBS or medium to a concentration not lower than 50 μg/mL.

Gene Information

• Gene Name: KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ]
• Official Symbol: KDR
• Synonyms: KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2
• Gene ID: 3791
• mRNA Refseq: NM_002253
• Protein Refseq: NP_002244
• MIM: 191306
• UniProt ID: P35968