Recombinant Human KDSR Protein, GST-tagged

• Cat.No.: KDSR-4572H
• Product Overview: Human FVT1 full-length ORF ( AAH08797.1, 12 a.a. - 332 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 61.05 kDa
• AA Sequence: FVLLLYMVSPLISPKPLALPGAHVV VTGGSSGIGKCIAIECYKQGAFITL VARNEDKLLQAKKEIEMHSINDKQV VLCISVDVSQDYNQVENVIKQAQEK LGPVDMLVNCAGMAVSGKFEDLEVS TFERLMSINYLGSVYPSRAVITTMK ERRVGRIVFVSSQAGQLGLFGFTAY SASKFAIRGLAEALQMEVKPYNVYI TVAYPPDTDTPGFAEENRTKPLETR LISETTSVCKPEQVAKQIVKDAIQG NFNSSLGSDGYMLSALTCGMAPVTS ITEGLQQVVTMGLFRTIALFYLGSF DSIVRRCMMQREKSENADKTA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: KDSR 3-ketodihydrosphingosine reductase [ Homo sapiens ]
• Official Symbol: KDSR
• Synonyms: KDSR; 3-ketodihydrosphingosine reductase; follicular lymphoma variant translocation 1, FVT1; 3 dehydrosphinganine reductase; DHSR; SDR35C1; short chain dehydrogenase/reductase family 35C; member 1; FVT-1; KDS reductase; 3-dehydrosphinganine reductase; follicular variant translocation protein 1; follicular lymphoma variant translocation 1; short chain dehydrogenase/reductase family 35C, member 1; FVT1; FLJ36555; FLJ92680
• Gene ID: 2531
• mRNA Refseq: NM_002035
• Protein Refseq: NP_002026
• MIM: 136440
• UniProt ID: Q06136