Recombinant Human KIAA0226 Protein, MYC/DDK-tagged

• Cat.No.: KIAA0226-406H
• Product Overview: Recombinant human KIAA0226 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 108.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: RUN and cysteine rich domain containing beclin 1 interacting protein [ Homo sapiens ]
• Official Symbol: RUBCN
• Synonyms: RUBICON; SCAR15
• Gene ID: 9711
• mRNA Refseq: NM_001145642.2
• Protein Refseq: NP_001139114.1
• MIM: 613516
• UniProt ID: Q92622