Recombinant Human KLB protein, His-tagged

• Cat.No.: KLB-539H
• Product Overview: Human Beta Klotho Protein is expressed from mammalian with a His Tag at the C-terminal. It contains Met30-Thr983.

Specification

• Description: Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4)
• Molecular Mass: The protein has a predicted MW of 111.6 kDa.Due to glycosylation, the protein migrates to 115- 125KDa based on Bis-Tris PAGE result.
• Protein length: Met30-Thr983
• Endotoxin: Less than 0.5EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.

Gene Information

• Gene Name: KLB klotho beta [ Homo sapiens (human) ]
• Official Symbol: KLB
• Synonyms: KLB; klotho beta; BKL; beta-klotho; b-Klotho; betaKlotho; klotho beta like; klotho beta-like protein
• Gene ID: 152831
• mRNA Refseq: NM_175737.3
• Protein Refseq: NP_783864.1
• UniProt ID: Q86Z14