Recombinant Human KSR1 Protein, 335-end, N-GST tagged

• Cat.No.: KSR1-60H
• Product Overview: Recombinant human KSR1 (335-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 335-end
• Description: Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer.
• Molecular Mass: 105 kDa
• Purity: The purity of KSR1 was determinedtobe > 70% by densitometry,approx. MW 105 kDa.
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA,0.25mMDTT, O.1mM PMSF, 25% glycerol.
• Shipping: Dry ice
• References: 1. Yan. et.al: Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J. Clin. Invest. 114: 1272-1280, 2004.
  2. Zhang. et.al: Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nature Med. 17: 341-346, 2011.

Gene Information

• Gene Name: KSR1 kinase suppressor of ras 1 [ Homo sapiens (human) ]
• Official Symbol: KSR1
• Synonyms: KSR1; kinase suppressor of ras 1; KSR; RSU2; kinase suppressor of Ras 1; EC 2.7.11.1
• Gene ID: 8844
• mRNA Refseq: NM_014238
• Protein Refseq: NP_055053
• MIM: 601132
• UniProt ID: A0A0A0MQW1