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Recombinant Human LGALS9 protein, His-tagged

Cat.No. : LGALS9-445H
Product Overview : Recombinant Human LGALS9 protein (Ala2-Thr323), fused to His tag at N-terminus, was expressed in human 293 cells (HEK293).
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Description : Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 um filtered solution in 20 mM MOPS, 50 mM NaCl, 1 mM EDTA, 2 mM DTT, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 36.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).
Protein length : 322
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : LGALS9
Official Symbol : LGALS9
Synonyms : LGALS9; lectin, galactoside-binding, soluble, 9; galectin-9; galectin 9; LGALS9A; gal-9; ecalectin; tumor antigen HOM-HD-21; urate transporter/channel protein; HUAT; MGC117375; MGC125973; MGC125974
Gene ID : 3965
mRNA Refseq : NM_002308
Protein Refseq : NP_002299
MIM : 601879
UniProt ID : O00182

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials involving LGALS9 protein? 04/12/2023

Yes, there are clinical trials investigating the use of LGALS9-based therapies in cancer treatment, with a focus on immunotherapy approaches.

Is LGALS9 protein being explored for the treatment of infectious diseases? 07/05/2022

There is emerging research on the potential use of LGALS9 in modulating immune responses to infectious diseases, particularly in the context of viral infections.

What are the potential challenges associated with the clinical application of LGALS9 protein? 03/28/2021

Challenges include optimizing the delivery and dosing of LGALS9-based therapies and addressing potential adverse effects on immune homeostasis.

How is LGALS9 protein being studied in the context of transplant immunology? 01/08/2020

LGALS9 is being investigated for its potential to induce immune tolerance and mitigate transplant rejection in preclinical studies.

How does LGALS9 protein contribute to cancer immunotherapy? 12/31/2019

LGALS9 has been found to promote the activation and proliferation of cytotoxic T lymphocytes, which are key players in the immune response against cancer cells.

Customer Reviews (3)

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08/04/2019

    It has demonstrated outstanding performance in ELISA, providing reliable and precise results.

    05/05/2019

      It has been invaluable in protein electron microscopy structure analysis, facilitating detailed investigations and yielding valuable insights.

      03/09/2016

        I highly recommend the LGALS9 protein for various experimental applications.

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