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Recombinant Human LGMN Protein

Cat.No. : LGMN-01H
Product Overview : Recombinant Human LGMN Protein without tag was expressed in Leishmania.
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  • Gene Information
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Description : This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
Source : Leishmania
Species : Human
Form : Liquid
Molecular Mass : 36 kDa
Purity : > 90 % (SDS-PAGE)
Stability : Shelf Life: 12 months
Storage : Store at -20 centigrade. Avoid freeze/thaw cycles.
Concentration : 500 μg/mL
Storage Buffer : 20 mM citric acid pH 4.0, 100 mM NaCl, 2 mM DTT
Shipping : Gel packs
Gene Name : LGMN legumain [ Homo sapiens (human) ]
Official Symbol : LGMN
Synonyms : LGMN; legumain; AEP; LGMN1; PRSC1; legumain; asparaginyl endopeptidase; cysteine protease 1; protease, cysteine 1; protease, cysteine, 1 (legumain); EC 3.4.22.34
Gene ID : 5641
mRNA Refseq : NM_005606
Protein Refseq : NP_005597
MIM : 602620
UniProt ID : Q99538

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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