Active Recombinant Human LGR6 Protein, Fc-tagged

• Cat.No.: LGR6-26H
• Product Overview: Recombinant human LGR6 (Ala25-Ala567) protein fused with the Fc region of human IgG1 (Pro100-Lys330) at the C-terminus was expressed in Chinese Hamster Ovary cell line.

Specification

• Description: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.
• Source: CHO
• Species: Human
• Tag: Fc
• Predicted N Terminal: Ala25
• Bio-activity: Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is 2.5-12.5 μg/mL in the presence of 10 ng/mL Recombinant Mouse Wnt‑3a.
• Molecular Mass: 87 kDa
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• Purity: >80%, by SDS-PAGE with silver staining.
• Storage: Avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in PBS.

Gene Information

• Gene Name: LGR6
• Official Symbol: LGR6 leucine rich repeat containing G protein-coupled receptor 6 [ Homo sapiens (human) ]
• Synonyms: GPCR; VTS20631; FLJ14471; gonadotropin receptor; GPCR; leucine-rich repeat containing G protein-coupled receptor 6; leucine-rich repeat-containing G protein-coupled receptor 6; leucine-rich repeat-containing G-protein coupled receptor 6; Lgr6; LGR6 leucine rich repeat containing G protein-coupled receptor 6
• Gene ID: 59352
• mRNA Refseq: NM_021636
• Protein Refseq: NP_067649
• MIM: 606653
• UniProt ID: Q9HBX8