|Product Overview :||Recombinant human LGR6 (Ala25-Ala567) protein fused with the Fc region of human IgG1 (Pro100-Lys330) at the C-terminus was expressed in Chinese Hamster Ovary cell line.|
|Description :||This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.|
|Predicted N Terminal :||Ala25|
|Bio-activity :||Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is 2.5-12.5 μg/mL in the presence of 10 ng/mL Recombinant Mouse Wnt‑3a.|
|Molecular Mass :||87 kDa|
|Endotoxin :||<0.10 EU per 1 μg of the protein by the LAL method.|
|Purity :||>80%, by SDS-PAGE with silver staining.|
|Storage :||Avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Storage Buffer :||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution :||Reconstitute at 100 μg/mL in PBS.|
|Gene Name :||LGR6|
|Official Symbol :||LGR6 leucine rich repeat containing G protein-coupled receptor 6 [ Homo sapiens (human) ]|
|Synonyms :||GPCR; VTS20631; FLJ14471; gonadotropin receptor; GPCR; leucine-rich repeat containing G protein-coupled receptor 6; leucine-rich repeat-containing G protein-coupled receptor 6; leucine-rich repeat-containing G-protein coupled receptor 6; Lgr6; LGR6 leucine rich repeat containing G protein-coupled receptor 6|
|Gene ID :||59352|
|mRNA Refseq :||NM_021636|
|Protein Refseq :||NP_067649|
|UniProt ID :||Q9HBX8|