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Recombinant Human LINGO1 Protein, His-tagged

Cat.No. : LINGO1-001H
Product Overview : Recombinant human LINGO1 (a non-glycosylated polypeptide chain containing 133 amino acids (241-337 a.a)) fused to a 36 amino acid His-tag at N-terminus was expressed in E.coli.
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  • Gene Information
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Description : Leucine Rich Repeat And Ig Domain Containing 1, also known as Lingo1 is primarily expressed in neuronal tissue, and most abundantly in the cortex. In addition, Lingo 1 is involved in the inhibition of axon regeneration all the way through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is accomplished through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system. Furthermore, LINGO-1 inhibits oligodendrocyte precursor differentiation as well as myelination, by a mechanism which also involves activation of RhoA, however it appears that it does not require 75 or NgR1.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 15.1kDa
AA Sequence : MRGSHHHHHHGMASMTGGQQMGRDL YDDDDKDRWGSLKVLEISHWPYLDT MTPNCLYGLNLTSLSITHCNLTAVP YLAVRHLVYLRFLNLSYNPISTIEG SMLHELLRLQEIQLVGGQLAVVEPY AFRGLNYL
Purity : Greater than 90.0% as determined by SDS-PAGE.
Storage : Store at 4 centigrade if entire vial will be used within 2-4 weeks. Store, frozen at -20 centigrade for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Concentration : 1mg/mL
Storage Buffer : 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol
Gene Name : LINGO1
Official Symbol : LINGO1 leucine rich repeat and Ig domain containing 1 [ Homo sapiens (human) ]
Synonyms : Leucine Rich Repeat And Ig Domain Containing 1; LRRN6A; Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1; Leucine-Rich Repeat Neuronal Protein 1; Leucine Rich Repeat Neuronal 6A; LERN1; Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1; Leucine-Rich Repeat Neuronal Protein 6A; UNQ201; LERN1; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; LINGO1; leucine rich repeat and Ig domain containing 1; ERN1
Gene ID : 84894
mRNA Refseq : NM_001301186
Protein Refseq : NP_001288115
MIM : 609791
UniProt ID : Q96FE5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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