Recombinant Human LRRFIP2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: LRRFIP2-495H
• Product Overview: LRRFIP2 MS Standard C13 and N15-labeled recombinant protein (NP_001127841) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 48.1 kDa
• AA Sequence: MGTPASGRKRTPVKDRFSAEDEALS NIAREAEARLAAKRAARAEARDIRM RELERQQKELDEKSDKQYAENYTRP SSRNSASATTPLSGNSSRRGSGDTS SLIDPDTSLSELRDIYDLKDQIQDV EGRYMQGLKELKESLSEVEEKYKKA MVSNAQLDNEKNNLIYQVDTLKDVI EEQEEQMAEFYRENEEKSKELERQK HMCSVLQHKMEELKEGLRQRDELIE KHGLVIIPDGTPNGDVSHEPVAGAI TVVSQEAAQVLESAGEGPLDVRLRK LAGEKEELLSQIRKLKLQLEEERQK CSRNDGTVGDLAGLQNGSDLQFIEM QRDANRQISEYKFKLSKAEQDITTL EQSISRLEGQVLRYKTAAENAEKVE DELKAEKRKLQRELRTALDKIEEME MTNSHLAKRLEKMKANRTALLAQQT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: LRRFIP2 LRR binding FLII interacting protein 2 [ Homo sapiens (human) ]
• Official Symbol: LRRFIP2
• Synonyms: LRRFIP2; leucine rich repeat (in FLII) interacting protein 2; leucine-rich repeat flightless-interacting protein 2; HUFI 2; LRR FLII-interacting protein 2; HUFI-2; FLJ20248; FLJ22683; FLJ58304; DKFZp434H2035
• Gene ID: 9209
• mRNA Refseq: NM_001134369
• Protein Refseq: NP_001127841
• MIM: 614043
• UniProt ID: Q9Y608