| Description : |
This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
92.1 kDa |
| AA Sequence : |
MSLLGDPLQALPPSAAPTGPLLAPP AGATLNRLREPLLRRLSELLDQAPE GRGWRRLAELAGSRGRLRLSCLDLE QCSLKVLEPEGSPSLCLLKLMGEKG CTVTELSDFLQAMEHTEVLQLLSPP GIKITVNPESKAVLAGQFVKLCCRA TGHPFVQYQWFKMNKEIPNGNTSEL IFNAVHVKDAGFYVCRVNNNFTFEF SQWSQLDVCDIPESFQRSVDGVSES KLQICVEPTSQKLMPGSTLVLQCVA VGSPIPHYQWFKNELPLTHETKKLY MVPYVDLEHQGTYWCHVYNDRDSQD SKKVEIIIGRTDEAVECTEDELNNL GHPDNKEQTTDQPLAKDKVALLIGN MNYREHPKLKAPLVDVYELTNLLRQ LDFKVVSLLDLTEYEMRNAVDEFLL LLDKGVYGLLYYAGHGYENFGNSFM VPVDAPNPYRSENCLCVQNILKLMQ EKETGLNVFLLDMCRKRNDYDDTIP ILDALKVTANIVFGYATCQGAEAFE IQHSGLANGIFMKFLKDRLLEDKKI TVLLDEVAEDMGKCHLTKGKQALEI RSSLSEKRALTDPIQGTEYSAESLV RNLQWAKAHELPESMCLKFDCGVQI QLGFAAEFSNVMIIYTSIVYKPPEI IMCDAYVTDFPLDLDIDPKDANKGT PEETGSYLVSKDLPKHCLYTRLSSL QKLKEHLVFTVCLSYQYSGLEDTVE DKQEVNVGKPLIAKLDMHRGLGRKT CFQTCLMSNGPYQSSAATSGGAGHY HSLQDPFHGVYHSHPGNPSNVTPAD SCHCSRTPDAFISSFAHHASCHFSR SNVPVETTDEIPFSFSDRLRISEKT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
