Recombinant Human MAP1LC3B Protein (Met1-Gly120), His tagged

• Cat.No.: MAP1LC3B-3617H
• Product Overview: Recombinant human LC3B (Met1-Gly120) protein fused with His tag was expressed in E. coli.

Specification

• Description: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 15.38 kDa
• Protein Length: Met1-Gly120
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: MAP1LC3B microtubule-associated protein 1 light chain 3 beta [ Homo sapiens (human) ]
• Official Symbol: MAP1LC3B
• Synonyms: MAP1LC3B; microtubule-associated protein 1 light chain 3 beta; microtubule-associated proteins 1A/1B light chain 3B; ATG8F; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; MAP1 light chain 3-like protein 2; autophagy-related ubiquitin-like modifier LC3 B; LC3B; MAP1LC3B-a; MAP1A/1BLC3
• Gene ID: 81631
• mRNA Refseq: NM_022818
• Protein Refseq: NP_073729
• MIM: 609604
• UniProt ID: Q9GZQ8