| Description : |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
44.2 kDa |
| AA Sequence : |
MLARRKPVLPALTINPTIAEGPSPT SEGASEANLVDLQKKLEELELDEQQ KKRLEAFLTQKAKVGELKDDDFERI SELGAGNGGVVTKVQHRPSGLIMAR KLIHLEIKPAIRNQIIRELQVLHEC NSPYIVGFYGAFYSDGEISICMEHM DGGSLDQVLKEAKRIPEEILGKVSI AVLRGLAYLREKHQIMHRDVKPSNI LVNSRGEIKLCDFGVSGQLIDSMAN SFVGTRSYMAPERLQGTHYSVQSDI WSMGLSLVELAVGRYPIPPPDAKEL EAIFGRPVVDGEEGEPHSISPRPRP PGRPVSGHGMDSRPAMAIFELLDYI VNEPPPKLPNGVFTPDFQEFVNKCL IKNPAERADLKMLTNHTFIKRSEVE EVDFAGWLCKTLRLNQPGTPTRTAV TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
