Recombinant Human MAP2K6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MAP2K6-6391H
• Product Overview: MAP2K6 MS Standard C13 and N15-labeled recombinant protein (NP_002749) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 37.5 kDa
• AA Sequence: MSQSKGKKRNPGLKIPKEAFEQPQT SSTPPRDLDSKACISIGNQNFEVKA DDLEPIMELGRGAYGVVEKMRHVPS GQIMAVKRIRATVNSQEQKRLLMDL DISMRTVDCPFTVTFYGALFREGDV WICMELMDTSLDKFYKQVIDKGQTI PEDILGKIAVSIVKALEHLHSKLSV IHRDVKPSNVLINALGQVKMCDFGI SGYLVDSVAKTIDAGCKPYMAPERI NPELNQKGYSVKSDIWSLGITMIEL AILRFPYDSWGTPFQQLKQVVEEPS PQLPADKFSAEFVDFTSQCLKKNSK ERPTYPELMQHPFFTLHESKGTDVA SFVKLILGDTRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens (human) ]
• Official Symbol: MAP2K6
• Synonyms: MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK kinase 6; stress-activated protein kinase kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK-3
• Gene ID: 5608
• mRNA Refseq: NM_002758
• Protein Refseq: NP_002749
• MIM: 601254
• UniProt ID: P52564