Recombinant Human MB21D1 Protein (161-522 aa), His-SUMO-tagged MB21D1-2114H

Recombinant Human MB21D1 Protein (161-522 aa), His-SUMO-tagged

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Recombinant Human MB21D1 Protein (161-522 aa), His-SUMO-tagged

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Cat.No. : MB21D1-2114H
Product Overview : Recombinant Human MB21D1 Protein (161-522 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Partial.
Description : Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer,50% glycerol
Molecular Mass : 58.3 kDa
Protein length : 161-522 aa
AA Sequence : GASKLRAVLEKLKLS RDDISTAAGMVKGVV DHLLLRLKCDSAFRG VGLLNTGSYYEHVKI SAPNEFDVMFKLEVP RIQLEEYSNTRAYYF VKFKRNPKENPLSQF LEGEILSASKMLSKF RKIIKEEINDIKDTD VIMKRKRGGSPAVTL LISEKISVDITLALE SKSSWPASTQEGLRI QNWLSAKVRKQLRLK PFYLVPKHAKEGNGF QEETWRLSFSHIEKE ILNNHGKSKTCCENK EEKCCRKDCLKLMKY LLEQLKERFKDKKHL DKFSSYHVKTAFFHV CTQNPQDSQWDRKDL GLCFDNCVTYFLQCL RTEKLENYFIPEFNL FSSNLIDKRSKEFLT KQIEYERNNEFPVFD EF
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : MB21D1 Mab-21 domain containing 1 [ Homo sapiens ]
Official Symbol : MB21D1
Synonyms : MB21D1; protein MB21D1; C6orf150; MGC131892; MGC142166; MGC142168;
Gene ID : 115004
mRNA Refseq : NM_138441
Protein Refseq : NP_612450
MIM : 613973
UniProt ID : Q8N884

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