Description : |
The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. |
Source : |
E. coli |
Species : |
Mouse |
Tag : |
His & T7 |
Form : |
Freeze-dried powder |
Molecular Mass : |
Predicted Molecular Mass: 24.9kDa |
Protein length : |
Glu211~Lys395 (Accession # Q8C6L5) |
Endotoxin : |
<1.0EU per 1ug (determined by the LAL method) |
Purity : |
>95% |
Applications : |
SDS-PAGE; WB; ELISA; IP. |
Stability : |
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : |
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : |
Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : |
Reconstitute in sterile PBS, pH7.2-pH7.4. |
Isoelectric Point : |
9.4 |