Recombinant Human MBNL1 protein, MYC/DDK-tagged
Cat.No. : |
MBNL1-524H |
Product Overview : |
Recombinant Human MBNL1, transcript variant 6, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : |
This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
MYC/DDK |
Form : |
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : |
36.8 kDa |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : |
>50 ug/mL as determined by microplate BCA method |
Gene Name : |
MBNL1 muscleblind-like splicing regulator 1 [ Homo sapiens ] |
Official Symbol : |
MBNL1 |
Synonyms : |
MBNL1; muscleblind-like splicing regulator 1; MBNL, muscleblind (Drosophila) like , muscleblind like (Drosophila); muscleblind-like protein 1; EXP; EXP35; EXP40; EXP42; KIAA0428; triplet-expansion RNA-binding protein; MBNL; DKFZp686P06174; |
Gene ID : |
4154 |
mRNA Refseq : |
NM_207296 |
Protein Refseq : |
NP_997179 |
MIM : |
606516 |
UniProt ID : |
Q9NR56 |
Chromosome Location : |
3q25 |
Pathway : |
Adipogenesis, organism-specific biosystem; |
Function : |
RNA binding; double-stranded RNA binding; metal ion binding; nucleic acid binding; protein binding; zinc ion binding; |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.