| Description : |
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
71.4 kDa |
| AA Sequence : |
MGLPRLVCAFLLAACCCCPRVAGVP GEAEQPAPELVEVEVGSTALLKCGL SQSQGNLSHVDWFSVHKEKRTLIFR VRQGQGQSEPGEYEQRLSLQDRGAT LALTQVTPQDERIFLCQGKRPRSQE YRIQLRVYKAPEEPNIQVNPLGIPV NSKEPEEVATCVGRNGYPIPQVIWY KNGRPLKEEKNRVHIQSSQTVESSG LYTLQSILKAQLVKEDKDAQFYCEL NYRLPSGNHMKESREVTVPVFYPTE KVWLEVEPVGMLKEGDRVEIRCLAD GNPPPHFSISKQNPSTREAEEETTN DNGVLVLEPARKEHSGRYECQGLDL DTMISLLSEPQELLVNYVSDVRVSP AAPERQEGSSLTLTCEAESSQDLEF QWLREETGQVLERGPVLQLHDLKRE AGGGYRCVASVPSIPGLNRTQLVNV AIFGPPWMAFKERKVWVKENMVLNL SCEASGHPRPTISWNVNGTASEQDQ DPQRVLSTLNVLVTPELLETGVECT ASNDLGKNTSILFLELVNLTTLTPD SNTTTGLSTSTASPHTRANSTSTER KLPEPESRGVVIVAVIVCILVLAVL GAVLYFLYKKGKLPCRRSGKQEITL PPSRKSELVVEVKSDKLPEEMGLLQ GSSGDKRAPGDQGEKYIDLRHTRTR PLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
