Recombinant Human MEN1 Protein, GST-tagged

• Cat.No.: MEN1-4445H
• Product Overview: Human MEN1 full-length ORF ( AAH02544.1, 1 a.a. - 575 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 90.1 kDa
• AA Sequence: MGLKAAQKTLFPLRSIDDVVRLFAA ELGREEPDLVLLSLVLGFVEHFLAV NRVIPTNVPELTFQPSPAPDPPGGL TYFPVADLSIIAALYARFTAQIRGA VDLSLYPREGGVSSRELVKKVSDVI WNSLSRSYFKDRAHIQSLFSFITGT KLDSSGVAFAVVGACQALGLRDVHL ALSEDHAWSWLYLKGSYMRCDRKME VAFMVCAINPSIDLHTDSLELLQLQ QKLLWLLYDLGHLERYPMALGNLAD LEELEPTPGRPDPLTLYHKGIASAK TYYRDEHIYPYMYLAGYHCRNRNVR EALQAWADTATVIQDYNYCREDEEI YKEFFEVANDVIPNLLKEAASLLEA GEERPGEQSQGTQSQGSALQDPECF AHLLRFYDGICKWEEGSPTPVLHVG WATFLVQSLGRFEGQVRQKVRIVSR EAEAAEAEEPWGEEAREGRRRGPRR ESKPEEPPPPKKPALDKGLGTGQGA VSGPPRKPPGTVAGTARGPEGGSTA QVPAPAASPPPEGPVLTFQSEKMKG MKELLVATKINSSAIKLQLTAQSQV QMKKQKVSTPSDYTLSFLKRQRKGL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MEN1 multiple endocrine neoplasia I [ Homo sapiens ]
• Official Symbol: MEN1
• Synonyms: MEN1; multiple endocrine neoplasia I; menin; endocrine adenomatosis, multiple; MEAI; SCG2; MENIN
• Gene ID: 4221
• mRNA Refseq: NM_000244
• Protein Refseq: NP_000235
• MIM: 613733
• UniProt ID: O00255