Recombinant Human MEOX1 Protein (1-254 aa), GST-tagged

• Cat.No.: MEOX1-2137H
• Product Overview: Recombinant Human MEOX1 Protein (1-254 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Cell Biology. Protein Description: Full Length.

Specification

• Description: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 55.0 kDa
• Protein length: 1-254 aa
• AA Sequence: MDPAASSCMRSLQPPAPVWGCLRNP HSEGNGASGLPHYPPTPFSFHQKPD FLATATAAYPDFSASCLAATPHSLP QEEHIFTEQHPAFPQSPNWHFPVSD ARRRPNSGPAGGSKEMGTSSLGLVD TTGGPGDDYGVLGSTANETEKKSSR RRKESSDNQENRGKPEGSSKARKER TAFTKEQLRELEAEFAHHNYLTRLR RYEIAVNLDLSERQVKVWFQNRRMK WKRVKGGQPISPNGQDPEDGDSTAS PSSE
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: MEOX1 mesenchyme homeobox 1 [ Homo sapiens ]
• Official Symbol: MEOX1
• Synonyms: MEOX1; mesenchyme homeobox 1; mesenchyme homeo box 1; MOX1
• Gene ID: 4222
• mRNA Refseq: NM_001040002
• Protein Refseq: NP_001035091
• MIM: 600147
• UniProt ID: P50221