Description : |
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
110 kDa |
AA Sequence : |
MSNSRNNRVMVEGVGARVVRGPDWK WGKQDGGEGHVGTVRSFESPEEVVV VWDNGTAANYRCSGAYDLRILDSAP TGIKHDGTMCDTCRQQPIIGIRWKC AECTNYDLCTVCYHGDKHHLRHRFY RITTPGSERVLLESRRKSKKITARG IFAGARVVRGVDWQWEDQDGGNGRR GKVTEIQDWSASSPHSAAYVLWDNG AKNLYRVGFEGMSDLKCVQDAKGGS FYRDHCPVLGEQNGNRNPGGLQIGD LVNIDLDLEIVQSLQHGHGGWTDGM FETLTTTGTVCGIDEDHDIVVQYPS GNRWTFNPAVLTKANIVRSGDAAQG AEGGTSQFQVGDLVQVCYDLERIKL LQRGHGEWAEAMLPTLGKVGRVQQI YSDSDLKVEVCGTSWTYNPAAVSKV ASAGSAISNASGERLSQLLKKLFET QESGDLNEELVKAAANGDVAKVEDL LKRPDVDVNGQCAGHTAMQAASQNG HVDILKLLLKQNVDVEAEDKDGDRA VHHAAFGDEGAVIEVLHRGSADLNA RNKRRQTPLHIAVNKGHLQVVKTLL DFGCHPSLQDSEGDTPLHDAISKKR DDILAVLLEAGADVTITNNNGFNAL HHAALRGNPSAMRVLLSKLPRPWIV DEKKDDGYTALHLAALNNHVEVAEL LVHQGNANLDIQNVNQQTALHLAVE RQHTQIVRLLVRAGAKLDIQDKDGD TPLHEALRHHTLSQLRQLQDMQDVG KVDAAWEPSKNTLIMGLGTQGAEKK SAASIACFLAANGADLSIRNKKGQS PLDLCPDPNLCKALAKCHKEKVSGQ VGSRSPSMISNDSETLEECMVCSDM KRDTLFGPCGHIATCSLCSPRVKKC LICKEQVQSRTKIEECVVCSDKKAA VLFQPCGHMCACENCANLMKKCVQC RAVVERRVPFIMCCGGKSSEDATDD ISSGNIPVLQKDKDNTNVNADVQKL QQQLQDIKEQTMCPVCLDRLKNMIF LCGHGTCQLCGDRMSECPICRKAIE RRILLYTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |