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Recombinant Human MIB1 Protein (5-332 aa), His-tagged

Cat.No. : MIB1-1257H
Product Overview : Recombinant Human MIB1 Protein (5-332 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial.
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Description : E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.1 Publication.
Source : E. coli
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 40.1 kDa
Protein length : 5-332 aa
AA Sequence : RNNRVMVEGVGARVVRGPDWKWGKQ DGGEGHVGTVRSFESPEEVVVVWDN GTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECT NYDLCTVCYHGDKHHLRHRFYRITT PGSERVLLESRRKSKKITARGIFAG ARVVRGVDWQWEDQDGGNGRRGKVT EIQDWSASSPHSAAYVLWDNGAKNL YRVGFEGMSDLKCVQDAKGGSFYRD HCPVLGEQNGNRNPGGLQIGDLVNI DLDLEIVQSLQHGHGGWTDGMFETL TTTGTVCGIDEDHDIVVQYPSGNRW TFNPAVLTKANIVRSGDAAQGAEGG TSQ
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Gene Name : MIB1 mindbomb E3 ubiquitin protein ligase 1 [ Homo sapiens ]
Official Symbol : MIB1
Synonyms : MIB1; DIP 1; KIAA1323; MIB; ZZANK2; ZZZ6; DIP-1; FLJ90676; MGC129659; MGC129660; DKFZp686I0769; DKFZp761M1710;
Gene ID : 57534
mRNA Refseq : NM_020774
Protein Refseq : NP_065825
MIM : 608677
UniProt ID : Q86YT6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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