Recombinant Human MIB1 Protein (5-332 aa), His-tagged
Cat.No. : | MIB1-1257H |
Product Overview : | Recombinant Human MIB1 Protein (5-332 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial. |
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- Gene Information
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Description : | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.1 Publication. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 40.1 kDa |
Protein length : | 5-332 aa |
AA Sequence : | RNNRVMVEGVGARVVRGPDWKWGKQ DGGEGHVGTVRSFESPEEVVVVWDN GTAANYRCSGAYDLRILDSAPTGIK HDGTMCDTCRQQPIIGIRWKCAECT NYDLCTVCYHGDKHHLRHRFYRITT PGSERVLLESRRKSKKITARGIFAG ARVVRGVDWQWEDQDGGNGRRGKVT EIQDWSASSPHSAAYVLWDNGAKNL YRVGFEGMSDLKCVQDAKGGSFYRD HCPVLGEQNGNRNPGGLQIGDLVNI DLDLEIVQSLQHGHGGWTDGMFETL TTTGTVCGIDEDHDIVVQYPSGNRW TFNPAVLTKANIVRSGDAAQGAEGG TSQ |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Gene Name : | MIB1 mindbomb E3 ubiquitin protein ligase 1 [ Homo sapiens ] |
Official Symbol : | MIB1 |
Synonyms : | MIB1; DIP 1; KIAA1323; MIB; ZZANK2; ZZZ6; DIP-1; FLJ90676; MGC129659; MGC129660; DKFZp686I0769; DKFZp761M1710; |
Gene ID : | 57534 |
mRNA Refseq : | NM_020774 |
Protein Refseq : | NP_065825 |
MIM : | 608677 |
UniProt ID : | Q86YT6 |
Products Types
◆ Recombinant Protein | ||
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MIB1-5548M | Recombinant Mouse MIB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mib1-4064M | Recombinant Mouse Mib1 Protein, Myc/DDK-tagged | +Inquiry |
MIB1-9556Z | Recombinant Zebrafish MIB1 | +Inquiry |
◆ Lysates | ||
MIB1-4324HCL | Recombinant Human MIB1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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