Recombinant Human MITF Protein, His-tagged

• Cat.No.: MITF-737H
• Product Overview: Recombinant Human MITF, transcript variant 4, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 46.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: MITF microphthalmia-associated transcription factor [ Homo sapiens ]
• Official Symbol: MITF
• Synonyms: MITF; microphthalmia-associated transcription factor; Waardenburg syndrome, type 2A , WS2, WS2A; bHLHe32; homolog of mouse microphthalmia; MI; class E basic helix-loop-helix protein 32; WS2; WS2A
• Gene ID: 4286
• mRNA Refseq: NM_000248
• Protein Refseq: NP_000239
• MIM: 156845
• UniProt ID: O75030