"MLL2" Related Products

Recombinant Human MLL2 protein, GST-tagged, Active

Cat.No.: MLL2-190H
Product Overview: Recombinant Human MLL2(5317-end) fused with GST tag at N-terminal was expressed in Insect cells.
Description: Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric tumors.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 2.5 nmol/min/mg
Molecular Mass: 51 kDa
Protein length: 5317-end
Purity: >80%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 [ Homo sapiens ]
Official Symbol: MLL2
Synonyms: MLL2; myeloid/lymphoid or mixed-lineage leukemia 2; TNRC21, trinucleotide repeat containing 21; histone-lysine N-methyltransferase MLL2; ALR; CAGL114; KMT2D; MLL4; ALL1-related protein; Kabuki make-up syndrome; lysine N-methyltransferase 2B; lysine N-meth
Gene ID: 8085
mRNA Refseq: NM_003482
Protein Refseq: NP_003473
MIM: 602113
UniProt ID: O14686
Chromosome Location: 12q13.12
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function: DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; transcription regulatory region DNA binding; transferase activity; zinc ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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