Recombinant Human MMP3
Cat.No. : | MMP3-39H |
Product Overview : | Recombinant Human Matrix Metalloproteinase-3 Human Recombinant produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 230 amino acids and having a molecular mass of 22 kDa. The MMP-3 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
- Download
Species : | Human |
Source : | E.coli |
Tag : | Non |
Description : | MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 98% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | The protein was lyophilized from a concentrated (1 mg/ml) solution with no additives. |
Biological Activity : | The specific activity was found to be ≥1,250 mU/mg protein (H. Nagase, et al; J. Biol. Chem. 269, 20952, 1994). One unit is defined as the amount of enzyme that hydrolyzes 1µmol of MCA-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)-NH2 per min. at 37°C, pH 7.0. |
Solubility : | It is recommended to reconstitute the lyophilized Stromelysin-1 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Stability : | Lyophilized Matrix Metalloproteinase-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MMP-3 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. |
Gene Name | MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ] |
Synonyms | matrix metallopeptidase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; transin-1; MMP3; MGC126103; matrix metalloproteinase 3; CHDS6; Transin-1; proteoglycanase; MGC126104; Matrix metalloproteinase-3; EC 3.4.24.17 |
Gene ID | 4314 |
mRNA Refseq | NM_002422 |
Protein Refseq | NP_002413 |
MIM | 185250 |
UniProt ID | P08254 |
Chromosome Location | 11q22.3 |
Function | calcium ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding |
◆ Recombinant Proteins | ||
PPPDE1-3990H | Recombinant Human PPPDE1 protein, His-tagged | +Inquiry |
Tulp3-6737M | Recombinant Mouse Tulp3 Protein, Myc/DDK-tagged | +Inquiry |
RFL25940YF | Recombinant Full Length Yarrowia Lipolytica Plasma Membrane Fusion Protein Prm1(Prm1) Protein, His-Tagged | +Inquiry |
HERC5-178H | Recombinant Human HERC5, His-tagged | +Inquiry |
SGPL1-3141H | Recombinant Human SGPL1 Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Native Proteins | ||
OAC-34 | Active Native Oxaloacetate decarboxylase | +Inquiry |
ELANE-8104H | Native Human Neutrophil Elastase | +Inquiry |
GPT-188S | Active Native Swine Glutamate Pyruvate Transaminase | +Inquiry |
HPIV2ag-272V | Native Parainfluenza Virus type 2(strain II ALTB cc 2056) Protein | +Inquiry |
Thrombin-20H | Active Native Pig Thrombin | +Inquiry |
◆ Cell & Tissue Lysates | ||
TAP1-1254HCL | Recombinant Human TAP1 293 Cell Lysate | +Inquiry |
JMJD8-5100HCL | Recombinant Human JMJD8 293 Cell Lysate | +Inquiry |
VIM-1907HCL | Recombinant Human VIM cell lysate | +Inquiry |
HTR3B-828HCL | Recombinant Human HTR3B cell lysate | +Inquiry |
IL10-2079HCL | Recombinant Human IL10 cell lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All MMP3 Products
Required fields are marked with *
My Review for All MMP3 Products
Required fields are marked with *
0
Inquiry Basket