Recombinant Human MMP3 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : MMP3-780H
Product Overview : MMP3 MS Standard C13 and N15-labeled recombinant protein (NP_002413) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 54 kDa
AA Sequence : MKSLPILLLLCVAVCSAYPLDGAAR GEDTSMNLVQKYLENYYDLEKDVKQ FVRRKDSGPVVKKIREMQKFLGLEV TGKLDSDTLEVMRKPRCGVPDVGHF RTFPGIPKWRKTHLTYRIVNYTPDL PKDAVDSAVEKALKVWEEVTPLTFS RLYEGEADIMISFAVREHGDFYPFD GPGNVLAHAYAPGPGINGDAHFDDD EQWTKDTTGTNLFLVAAHEIGHSLG LFHSANTEALMYPLYHSLTDLTRFR LSQDDINGIQSLYGPPPDSPETPLV PTEPVPPEPGTPANCDPALSFDAVS TLRGEILIFKDRHFWRKSLRKLEPE LHLISSFWPSLPSGVDAAYEVTSKD LVFIFKGNQFWAIRGNEVRAGYPRG IHTLGFPPTVRKIDAAISDKEKNKT YFFVEDKYWRFDEKRNSMEPGFPKQ IAEDFPGIDSKIDAVFEEFGFFYFF TGSSQLEFDPNAKKVTHTLKSNSWL NCTRTRPLEQKLISEEDLAANDILD YKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : MMP3 matrix metallopeptidase 3 [ Homo sapiens (human) ]
Official Symbol : MMP3
Synonyms : MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase), STMY, STMY1; stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; MGC126103; MGC126104;
Gene ID : 4314
mRNA Refseq : NM_002422
Protein Refseq : NP_002413
MIM : 185250
UniProt ID : P08254

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MMP3 (Matrix Metalloproteinase 3) facilitate extracellular matrix remodeling? 10/21/2022

MMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.

What is the impact of MMP3 on cancer metastasis and tumor microenvironment modulation? 07/04/2022

MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.

How do alterations in MMP3 expression or activity affect skin aging and the development of dermatological conditions? 10/19/2021

Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.

How does MMP3 influence cardiovascular diseases, particularly in atherosclerosis and aneurysm formation? 07/01/2021

MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.

What role does MMP3 play in the progression of arthritis and joint degeneration? 09/03/2019

MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.

What are the mechanisms by which MMP3 modulates inflammatory responses? 06/13/2019

MMP3 modulates inflammation, impacting tissue inflammation and repair processes.

How does MMP3 contribute to wound healing and tissue repair processes? 12/31/2018

MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.

Customer Reviews (3)

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Reviews
12/05/2020

    Critical expertise in protein engineering, a trusted partner in research.

    03/21/2020

      Swift and reliable protein sequencing, a key asset for our work.

      01/22/2020

        High-quality protein crystallography services, consistently delivers exceptional outcomes.

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