Recombinant Rabbit MMP3 Protein, His-tagged

• Cat.No.: MMP3-1124R
• Product Overview: Recombinant Rabbit MMP3 Protein (Phe101-Cys478) with His tag was expressed in E. coli.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
• Source: E. coli
• Species: Rabbit
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 46.4 kDa; Accurate Molecular Mass: 46 kDa
• Protein length: Phe101-Cys478
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Oryctolagus cuniculus ]
• Official Symbol: MMP3
• Synonyms: MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); stromelysin-1; SL-1; MMP-3; transin-1; matrix metalloproteinase 3; matrix metalloproteinase-3
• Gene ID: 100009111
• mRNA Refseq: NM_001082280
• Protein Refseq: NP_001075749
• UniProt ID: P28863

Reviews

12/05/2020

Critical expertise in protein engineering, a trusted partner in research.

03/21/2020

Swift and reliable protein sequencing, a key asset for our work.

01/22/2020

High-quality protein crystallography services, consistently delivers exceptional outcomes.

Q&As

How does MMP3 (Matrix Metalloproteinase 3) facilitate extracellular matrix remodeling?

MMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.

What is the impact of MMP3 on cancer metastasis and tumor microenvironment modulation?

MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.

How do alterations in MMP3 expression or activity affect skin aging and the development of dermatological conditions?

Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.

How does MMP3 influence cardiovascular diseases, particularly in atherosclerosis and aneurysm formation?

MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.

What role does MMP3 play in the progression of arthritis and joint degeneration?

MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.

What are the mechanisms by which MMP3 modulates inflammatory responses?

MMP3 modulates inflammation, impacting tissue inflammation and repair processes.

How does MMP3 contribute to wound healing and tissue repair processes?

MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.