Recombinant Human MMP9 Protein, GST-tagged

• Cat.No.: MMP9-5438H
• Product Overview: Human MMP9 full-length ORF ( AAH06093.1, 1 a.a. - 707 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 103.4 kDa
• AA Sequence: MSLWQPLVLVLLVLGCCFAAPRQRQ STLVLFPGDLRTNLTDRQLAEEYLY RYGYTRVAEMRGESKSLGPALLLLQ KQLSLPETGELDSATLKAMRTPRCG VPDLGRFQTFEGDLKWHHHNITYWI QNYSEDLPRAVIDDAFARAFALWSA VTPLTFTRVYSRDADIVIQFGVAEH GDGYPFDGKDGLLAHAFPPGPGIQG DAHFDDDELWSLGKGVVVPTRFGNA DGAACHFPFIFEGRSYSACTTDGRS DGLPWCSTTANYDTDDRFGFCPSER LYTRDGNADGKPCQFPFIFQGQSYS ACTTDGRSDGYRWCATTANYDRDKL FGFCPTRADSTVMGGNSAGELCVFP FTFLGKEYSTCTSEGRGDGRLWCAT TSNFDSDKKWGFCPDQGYSLFLVAA HEFGHALGLDHSSVPEALMYPMYRF TEGPPLHKDDVNGIRHLYGPRPEPE PRPPTTTTPQPTAPPTVCPTGPPTV HPSERPTAGPTGPPSAGPTGPPTAG PSTATTVPLSPVDDACNVNIFDAIA EIGNQLYLFKDGKYWRFSEGRGSRP QGPFLIADKWPALPRKLDSVFEEPL SKKLFFFSGRQVWVYTGASVLGPRR LDKLGLGADVAQVTGALRSGRGKML LFSGRRLWRFDVKAQMVDPRSASEV DRMFPGVPLDTHDVFQYREKAYFCQ DRFYWRVSSRSELNQVDQVGYVTYD ILQCPED
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [ Homo sapiens ]
• Official Symbol: MMP9
• Synonyms: MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); CLG4B, matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase) , matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2
• Gene ID: 4318
• mRNA Refseq: NM_004994
• Protein Refseq: NP_004985
• MIM: 120361
• UniProt ID: P14780