Recombinant Human MRE11 Protein (Pro375-Lys609), N-GST tagged

• Cat.No.: MRE11-3734H
• Product Overview: Recombinant human MRE11 (Pro375-Lys609) fused with the N-GST tag was expressed in E. coli.

Specification

• Description: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
• Source: E. coli
• Species: Human
• Tag: N-GST
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 53.69 kDa
• Protein Length: Pro375-Lys609
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02% NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: MRE11 MRE11 homolog, double strand break repair nuclease [ Homo sapiens (human) ]
• Official Symbol: MRE11
• Synonyms: MRE11; MRE11 homolog, double strand break repair nuclease; ATLD; HNGS1; MRE11A; MRE11B; double-strand break repair protein MRE11; AT-like disease; DNA recombination and repair protein; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11-like protein A; double-strand break repair protein MRE11A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A
• Gene ID: 4361
• mRNA Refseq: NM_005590
• Protein Refseq: NP_005581
• MIM: 600814
• UniProt ID: P49959