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Recombinant Human MSLN protein, His-Avi-tagged

Cat.No. : MSLN-7818H
Product Overview : Recombinant Human MSLN protein(Q13421-2)(Glu296-Gly580), fused with C-terminal His and Avi tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : C-His-Avi
Protein length : Glu296-Gly580
Form : Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized Human MSLN, His Tag at 0.5μg/ml (100μl/Well). Dose response curve for Anti-MSLN Antibody, hFc Tag with the EC50 of 12.4ng/ml determined by ELISA.
Molecular Mass : The protein has a predicted MW of 35.2 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Endotoxin : Less than 1EU per μg by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Storage : Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Reconstitution : Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Gene Name : MSLN mesothelin [ Homo sapiens ]
Official Symbol : MSLN
Synonyms : MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP;
Gene ID : 10232
mRNA Refseq : NM_001177355
Protein Refseq : NP_001170826
MIM : 601051
UniProt ID : Q13421

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
05/22/2022

    Very satisfied, great product.

    03/06/2022

      Product is high-quality.

      09/30/2021

        Excellent for experiments, reliable.

        Q&As (7)

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        What is the primary role of MSLN in normal tissues? 12/07/2022

        MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

        How is MSLN expression altered in cancerous cells? 03/19/2022

        In cancer, MSLN expression is significantly upregulated.

        In which types of cancer is MSLN overexpressed? 03/28/2021

        MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

        Are there any therapeutic strategies targeting MSLN in cancer treatment? 02/25/2020

        Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

        How can MSLN levels be detected and measured in clinical settings? 10/07/2019

        MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

        What is the prognostic significance of MSLN overexpression in cancer patients? 11/23/2018

        MSLN overexpression is often associated with poor prognosis in cancer patients.

        How does MSLN contribute to cancer progression and metastasis? 11/07/2018

        MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.

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