Active Recombinant Human MSLN Protein, His-Avi-tagged, Biotinylated
Cat.No. : | MSLN-303H |
Product Overview : | Biotinylated Human Mesothelin(aa 296-580) is expressed from HEK293 cells. It contains AA Glu 296 - Gly 580 (Accession # AAH09272.1). This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. |
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Source : | HEK293 |
Species : | Human |
Tag : | His-Avi |
Predicted N Terminal : | Glu 296 |
Form : | Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose. |
Bio-activity : | Immobilized Anti-Human MSLN Mab at 0.5 ug/mL (100 uL/well) can bind Biotinylated Human Mesothelin, His Tag, Avi Tag with a linear range of 0.1-0.78 ug/mL. |
Molecular Mass : | The protein has a calculated MW of 35.9 kDa. The protein migrates as 45-60 kDa under reducing condition (SDS-PAGE) due to glycosylation. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Characteristic : | Biotinylation of this product is performed using Avitag technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin. The biotin to protein ratio is 0.5-1 as determined by the HABA assay. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20ºC or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8ºC for 12 months in lyophilized state; -70ºC for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | MSLN mesothelin [ Homo sapiens ] |
Official Symbol : | MSLN |
Synonyms : | MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP; |
Gene ID : | 10232 |
mRNA Refseq : | NM_001177355 |
Protein Refseq : | NP_001170826 |
MIM : | 601051 |
UniProt ID : | Q13421 |
Products Types
◆ Recombinant Protein | ||
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MSLN-3449R | Recombinant Rat MSLN Protein, His (Fc)-Avi-tagged | +Inquiry |
MSLN-382H | Recombinant Human MSLN Protein, His-tagged | +Inquiry |
Msln-4192M | Recombinant Mouse Msln Protein, Myc/DDK-tagged | +Inquiry |
MSLN-1139H | Recombinant Human MSLN Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MSLN-1316HCL | Recombinant Human MSLN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.
In cancer, MSLN expression is significantly upregulated.
MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.
Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.
MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.
MSLN overexpression is often associated with poor prognosis in cancer patients.
MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.
Customer Reviews (3)
Write a reviewVery satisfied, great product.
Product is high-quality.
Excellent for experiments, reliable.
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