Active Recombinant Human MSR1 Protein, Fc-tagged

• Cat.No.: MSR1-01H
• Product Overview: The recombinant human MSR1/CD204-Fc fusion is expressed as a 603 amino acid protein consisting of Lys77 - Leu451 region of MSR1/CD204 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions was expressed in Human cells.

Specification

• Description: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
• Source: Human cells
• Species: Human
• Tag: Fc
• Bio-activity: Binds to advanced glycation endproducts of bovine serum albumin (AGE­BSA) by ELISA
• Molecular Mass: 66.9 kDa
• Protein length: 77-451
• AA Sequence: KWETKNCSVSSTNANDITQSLTGKG NDSEEEMRFQEVFMEHMSNMEKRIQ HILDMEANLMDTEHFQNFSMTTDQR FNDILLQLSTLFSSVQGHGNAIDEI SKSLISLNTTLLDLQLNIENLNGKI QENTFKQQEEISKLEERVYNVSAEI MAMKEEQVHLEQEIKGEVKVLNNIT NDLRLKDWEHSQTLRNITLIQGPPG PPGEKGDRGPTGESGPRGFPGPIGP PGLKGDRGAIGFPGSRGLPGYAGRP GNSGPKGQKGEKGSGNTLTPFTKVR LVGGSGPHEGRVEILHSGQWGTICD DRWEVRVGQVVCRSLGYPGVQAVHK AAHFGQGTGPIWLNEVFCFGRESSI EECKIRQWGTRACSHSEDAGVTCTL STGTHTCPPCPAPELLGGPSVFLFP PKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREE QYNSTYRVVSVLTVLHQDWLNGKEY KCKVSNKALPAPIEKTISKAKGQPR EPQVYTLPPSREEMTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKTT PPVLDSDGSFFLYSKLTVDKSRWQQ GNVFSCSVMHEALHNHYTQKSLSLS PGK
• Endotoxin: <0.1 EU/μg of purified recombinant protein determined by the LAL method
• Purity: >95% judged by SDS-PAGE under reducing condition.
• Storage Buffer: Supplied at 0.25 mg/ml in sterile PBS pH7.4 (carrier and preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule) using the standard procedure.

Gene Information

• Gene Name: MSR1 macrophage scavenger receptor 1 [ Homo sapiens (human) ]
• Official Symbol: MSR1
• Synonyms: MSR1; macrophage scavenger receptor 1; SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII; macrophage scavenger receptor types I and II; macrophage acetylated LDL receptor I and II; macrophage scavenger receptor type III; scavenger receptor class A member 1
• Gene ID: 4481
• mRNA Refseq: NM_002445
• Protein Refseq: NP_002436
• MIM: 153622
• UniProt ID: P21757

Reviews

03/19/2022

No more worries about protein sourcing. This product is a lifesaver in the lab.

07/03/2020

Outstanding service! Quick response to inquiries and prompt shipping. A+

10/26/2019

This is a must-have in any lab. Consistent quality and great results every time.

Q&As

What is the primary function of the MSR1 protein, and in which cellular processes does it play a crucial role?

MSR1 (Macrophage Scavenger Receptor 1) is involved in the recognition and clearance of modified low-density lipoproteins (LDL) by macrophages, playing a critical role in lipid homeostasis.

How does MSR1 contribute to the resolution of inflammation, and what mechanisms are involved in its anti-inflammatory effects?

MSR1 contributes to the resolution of inflammation by promoting the clearance of apoptotic cells and debris. Its anti-inflammatory effects involve modulating cytokine production and signaling.

What role does MSR1 play in antigen presentation and T-cell activation within the immune system?

MSR1 participates in antigen presentation by macrophages, influencing T-cell activation. This role connects MSR1 to adaptive immune responses.

What is the relationship between MSR1 and the clearance of amyloid-beta peptides, and how does this link to neurodegenerative diseases?

MSR1 is involved in the clearance of amyloid-beta peptides associated with neurodegenerative diseases such as Alzheimer's. Its role in phagocytosis and clearance is crucial in the context of neuroinflammation.

How does MSR1 contribute to the immune response, and what are its implications in the context of inflammation and atherosclerosis?

MSR1 modulates the immune response by regulating inflammatory signaling pathways. Its involvement in recognizing modified LDL in atherosclerotic plaques links it to inflammation and atherosclerosis.