Species : |
Human |
Source : |
E.coli |
Tag : |
His |
Protein Length : |
193 amino acids |
Description : |
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. |
Conjugation : |
HIS |
Molecular Weight : |
24.400kDa inclusive of tags |
Tissue specificity : |
Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine. |
Form : |
Liquid |
Purity : |
>90% by SDS-PAGE |
Storage buffer : |
Preservative: NoneConstituents: 40% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8 |
Storage : |
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : |
MGSSHHHHHH SSGLVPRGSH MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD ASKFAEHVFRTFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNRDGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF |
Sequence Similarities : |
Belongs to the recoverin family.Contains 4 EF-hand domains. |